Biocompatibility Evaluation of Piezoelectric Materials through Cytotoxicity Test
Yasutomo UETSUJI, Takahiro UEDA, Hwishim HWANG,Yoshiaki HIRANO, Kazuyoshi TSUCHIIYA and Eiji NAKAMACHI
Abstract:Biocompatible piezoelectric materials are becoming increasingly important for actuators and sensors in medical devices. In this paper, we highlighted on some perovskite-type oxides MgSiO3, CaSiO3 and CaTiO3 of biocompatible piezoelectric materials discovered by first-principles calculation in our previous studies. In order to verify their biocompatibility, the cytotoxicity of similar oxides with the same components was examined as comparing with typical perovskite-type oxides Pb(Zr, Ti)O3 and BaTiO3. The fibroblast (L929) cells were cultured during 7 days and the effect of materials was evaluated by relative proliferation ratio and doubling time. As a result, it was recognized that MgSiO3 and CaTiO3 has the higher biocompatibility. On the other hand, CaSiO3 and Pb(Zr, Ti)O3 shows the strong toxicity and they can't be applied to medical devices. Key Words:Biomaterial, Piezoelectric Material, Perovskite-type Oxides, Cytotoxicity, Biocompatibility